Syntheses of 6-Deoxyhex-5-enopyranosides from 6-Bromo-6-deoxy- or 6-O-p-Tolylsulfonylhexopyranosides by the Use of DBU in DMSO
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چکیده
منابع مشابه
Mechanisms of inactivation of human S-adenosylhomocysteine hydrolase by 5',5',6',6'-tetradehydro-6'-deoxy-6'-halohomoadenosines.
In an effort to design more specific and potent inhibitors of S-adenosylhomocysteine (AdoHcy) hydrolase, we investigated the mechanisms by which 5',5',6', 6'-tetradehydro-6'-deoxy-6'-halohomoadenosines (X = Cl, Br, I) inactivated this enzyme. The 6'-chloro (a) and 6'-bromo (b) acetylenic nucleoside analogues produced partial ( approximately 50%) loss of enzyme activity with a concomitant ( appr...
متن کاملMechanism of inactivation of S-adenosylhomocysteine hydrolase by (E)-5',6'-didehydro-6'-deoxy-6'-halohomoadenosines.
S-Adenosylhomocysteine (AdoHcy) hydrolase is irreversibly inactivated by (E)-5',6'-didehydro-6'-deoxy-6'-halohomoadenosines (EDDHHAs, halogen = I, Br, and Cl). The inactivation is concomitant with the reduction of the enzyme-bound NAD+ (E.NAD+) to NADH, the release of halide ion, and the formation of adenine (Ade) from the EDDHHAs. The mechanism of this inactivation involves two catalytic pathw...
متن کاملPreparation of 6-azafulleroid-6-deoxy-2,3-di-O-myristoylcellulose.
6-Azafulleroid-6-deoxy-2,3-di-O-myristoylcellulose (3) was synthesized from 6-azido-6-deoxycellulose (1) by two reaction steps. The myristoylation of compound 1 with myristoyl chloride/pyridine proceeded smoothly to give 6-azido-6-deoxy-2,3-di-O-myristoylcellulose (2) in 97.0% yield. The reaction of compound 2 with fullerene (C(60)) was carried out by microwave heating to afford compound 3 in h...
متن کاملMethyl 5-bromo-6-methylpicolinate
The title compound, C(8)H(8)BrNO(2), does not show any significant inter-molecular π-π or C-H⋯π inter-actions in the crystal packing except for one weak Br⋯Br [3.715 (1) Å] inter-action.
متن کاملDiscussion on the regioselectivity of aminolysis of 5-bromo-2,4- dichloro-6-methylpyrimidine in ethanole
Crystallographic data analyses indicate that three types of prolinium cations, along with two types of hydrogen bonding, produce and stabilize the helical structure of triprolinium 12-phosphomolybdate. There are similarities between this organic-inorganic compound and peptides/proteins. The stronger “conventional” hydrogen bonds and the less common C-H…O attractions play critical roles in g...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1993
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.66.1156